Publications

PubMed Link

Naiman, N., Fujioka, K., Fujino, M., Valerius, M.T., Potter, S.S., McMahon, A.P., and Kobayashi, A. (2017). Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell 41, 349–365.e3. PMCID: PMC5532731

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA. (Re)Building a Kidney. J Am Soc Nephrol. 2017 May;28(5):1370–8. PMCID: PMC5407737

Tögel, F., Valerius, M.T., Freedman, B.S., Iatrino, R., Grinstein, M., and Bonventre, J.V. (2017). Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. JCI Insight 2, e88848. PMCID: PMC5256143 *Authors contributed equally.

Masuzaki, R., Zhao, S., Valerius, M.T., Tsugawa, D., Oya, Y., Ray, K.C., and Karp, S.J. (2016). SOCS2 Balances Metabolic and Restorative Requirements during Liver Regeneration. J. Biol. Chem. 291, 3346–3358. PMCID: PMC4751379

Valerius, M.T. (2016). Human Kidney Organoids: Nephron Models of Development and Disease. Transplantation 100, 1171–1172.

Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV (2015). Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun 6, 8715.

Morizane, R., Lam, A.Q., Freedman, B.S., Kishi, S., Valerius, M.T., and Bonventre, J.V. (2015). Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol October 12.

Baek, J.-H., Zeng, R., Weinmann-Menke, J., Valerius, M.T., Wada, Y., Ajay, A.K., Colonna, M., and Kelley, V.R. (2015). IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest 125, 3198–3214. PMCID: PMC4563757

Lindström NO, Chang C-H, Valerius MT, Hohenstein P, Davies JA. Node retraction during patterning of the urinary collecting duct system. J Anat. 2014 Oct 8.

Lam, A.Q., Freedman, B.S., Morizane, R., Lerou, P.H., Valerius, M.T., and Bonventre, J.V. (2014). Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. Journal of the American Society of Nephrology 25, 1211–1225. PMCID: PMC4033376

Park, J.-S., Ma, W., O'Brien, L.L., Chung, E., Guo, J.-J., Cheng, J.-G., Valerius, M.T., McMahon, J.A., Wong, W.H., and McMahon, A.P. (2012). Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012 Sep 11;23(3):637–51. PMCID: PMC3892952

Balasubramanian, S., Jansen, M., Valerius, M.T., Humphreys, B.D., and Strom, T.B. (2012). Orphan nuclear receptor nur77 promotes acute kidney injury and renal epithelial apoptosis. Journal of the American Society of Nephrology 23, 674–686. PMCID: PMC3312507

Valerius, M.T. (2012). Bowman's β-catenin. Journal of the American Society of Nephrology 23, 3–4.

Wiese, C.B., Ireland, S., Fleming, N.L., Yu, J., Valerius, M.T., Georgas, K., Chiu, H.S., Brennan, J., Armstrong, J., Little, M.H., et al. (2012). A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci 6, 130. PMCID: PMC3439845

Yu, J., Valerius, M.T., Duah, M., Staser, K., Hansard, J.K., Guo, J.-J., McMahon, J., Vaughan, J., Faria, D., Georgas, K., et al. (2012). Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 139, 1863–1873. PMCID: PMC3328182

Balasubramanian, S., Kota, S.K., and Valerius, M.T. (2011). The rejection barrier to induced pluripotent stem cells. J Am Soc Nephrol 22, 1583–1586.

Boyle, S.C., Kim, M., Valerius, M.T., McMahon, A.P., and Kopan, R. (2011). Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development 138, 4245–4254. PMCID: PMC3171224

Nagalakshmi, V.K., Ren, Q., Pugh, M.M., Valerius, M.T., McMahon, A.P., and Yu, J. (2011). Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int 79, 317–330. PMCID: PMC3214622

Humphreys, B.D., Lin, S.-L., Kobayashi, A., Hudson, T.E., Nowlin, B.T., Bonventre, J.V., Valerius, M.T., McMahon, A.P., and Duffield, J.S. (2010). Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176, 85–97. PMCID: PMC2797872

Georgas, K., Rumballe, B., Valerius, M.T., Chiu, H.S., Thiagarajan, R.D., Lesieur, E., Aronow, B.J., Brunskill, E.W., Combes, A.N., Tang, D., et al. (2009). Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol 332, 273–286. PMCID: NIHMS123047

Brunskill, E.W., Aronow, B.J., Georgas, K., Rumballe, B., Valerius, M.T., Aronow, J., Kaimal, V., Jegga, A.G., Yu, J., Grimmond, S., et al. (2008). Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell 15, 781–791. PMCID: PMC2653061

Humphreys, B.D., Valerius, M.T., Kobayashi, A., Mugford, J.W., Soeung, S., Duffield, J.S., McMahon, A.P., and Bonventre, J.V. (2008). Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2, 284–291.

Kobayashi, A., Valerius, M.T., Mugford, J.W., Carroll, T.J., Self, M., Oliver, G., and McMahon, A.P. (2008). Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 3, 169–181. PMCID: PMC2561900 MCB News Story

Valerius, M.T., and McMahon, A.P. (2008). Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns 8, 297–306. PMCID: PMC2435058

Cheng, H.-T., Kim, M., Valerius, M.T., Surendran, K., Schuster-Gossler, K., Gossler, A., McMahon, A.P., and Kopan, R. (2007). Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134, 801–811. PMCID: PMC2613851

Little, M. H., Brennan, J., Georgas, K., Davies, J. A., Davidson, D. R., Baldock, R. A., Beverdam, A., Bertram, J. F., Capel, B., Chiu, H. S., Valerius, M. T., et al. (28 authors) (2007). A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns 7, 680-699. PMCID: PMC2117077

*Park, J.P., *Valerius, M.T., and McMahon, A.P. (2007). Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development 134, 2533-2539. *Authors contributed equally.

Gray, P. A., Fu, H., Luo, P., Zhao, Q., Yu, J., Ferrari, A., Tenzen, T., Yuk, D. I., Tsung, E. F., Cai, Z., Alberta J. A., Cheng L. P., Liu Y., Stenman J. M., Valerius M. T., et al. (22 authors) (2004). Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306, 2255-2257.

Yu, J., McMahon, A.P., and Valerius, M.T. (2004). Recent genetic studies of mouse kidney development. Curr Opin Genet Dev 14, 550–557.

Potter, S.S., Valerius, M.T., and Brunskill, E.W. (2002). Using progenitor cells and gene chips to define genetic pathways. Methods Mol Biol 185, 269–284.

Valerius, M.T., Patterson, L.T., Feng, Y., and Potter, S.S. (2002a). Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. Proc Natl Acad Sci USA 99, 8090–8095. PMCID: PMC123025

Valerius, M.T., Patterson, L.T., Witte, D.P., and Potter, S.S. (2002b). Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation. Mech Dev 112, 219–232.

Branford, W.W., Zhao, G.Q., Valerius, M.T., Weinstein, M., Birkenmeier, E.H., Rowe, L.B., and Potter, S.S. (1997). Spx1, a novel X-linked homeobox gene expressed during spermatogenesis. Mech Dev 65, 87–98.

Haynes, T.L., Thomas, M.B., Dusing, M.R., Valerius, M.T., Potter, S.S., and Wiginton, D.A. (1996). An enhancer LEF-1/TCF-1 site is essential for insertion site-independent transgene expression in thymus. Nucleic Acids Res 24, 5034–5044. PMCID: PMC146351

Li, H., Zeitler, P.S., Valerius, M.T., Small, K., and Potter, S.S. (1996). Gsh-1, an orphan Hox gene, is required for normal pituitary development. Embo J 15, 714–724. PMCID: PMC450270

Aronow, B.J., Ebert, C.A., Valerius, M.T., Potter, S.S., Wiginton, D.A., Witte, D.P., and Hutton, J.J. (1995). Dissecting a locus control region: facilitation of enhancer function by extended enhancer-flanking sequences. Mol Cell Biol 15, 1123–1135. PMCID: PMC232021

Valerius, M.T., Li, H., Stock, J.L., Weinstein, M., Kaur, S., Singh, G., and Potter, S.S. (1995). Gsh-1: a novel murine homeobox gene expressed in the central nervous system. Dev Dyn 203, 337–351.

Kern, M.J., Witte, D.P., Valerius, M.T., Aronow, B.J., and Potter, S.S. (1992). A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy. Nucleic Acids Res 20, 5189–5195. PMCID: PMC334304


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